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The first aim is to perform planning, assessment, and resource development to conduct Phase I pilot studies and larger Phase II studies. This aim will be accomplished through site visits, supplemented by e-mail and telephone communication. This will include a detailed orientation of OCIM investigators to the approaches and research work liver of SVYASA investigators and further development of the collaborative relationships between investigators at the two institutions. OCIM will ensure that the current Institutional Review Board at SVYASA meets NIH standards. The second aim will be to provide training of SVYASA and OCIM liver investigators to liver prepare for additional studies. This will include using an established two-month UCSF advanced Training in Clinical Research Core program, with tailored supplemental training in areas identified as needs by SVYASA faculty. This experience will also be used to plan for future training of SVYASA faculty at UCSF, including training of new investigators and year-long sabbatical experiences for senior faculty.
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