The consortium will develop outpatient hepatobiliary

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The consortium will develop a grant application for an International Center for Research on Complementary and Alternative Medicine (ICRC) for funding to support three pilot projects related to irritable bowel syndrome and three cores (pharmacologic core, data management, analysis and hepatobiliary coordination core, and an administrative core). The hepatobiliary projects to be proposed will include: 1) a rat model irritable bowel syndrome treatment trial using acupuncture and herbs; 2) a human pathophysiology pilot study on the effect of TCM on cerebral cortical activation and visceral sensation to rectal distension in IBS patients and non-IBS volunteers; and hepatobiliary 3) Phase I and II clinical trials of TCM treatment in diarrhea-type IBS patients. Pilot studies in the animal model, standardization and authentication of the herbal preparation, and the techniques of human rectal distension in the functional MRI environment will be conducted in the planning phase to facilitate the projects to be proposed.
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