Subjects were 79 adults federal government grants uterine

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Subjects were 79 adults from families with a known HNPCC-predisposing mutation and with no prior history of CRC. Prior to genetic counseling, 53% (n=42) had ever had a colonoscopy.  After genetic testing, 33% (n=26) were positive for an HNPCC-predisposing mutation. There was no difference in baseline prevalence of colonoscopy use between uterine mutation carriers and non-carriers (50% and 54%, uterine respectively). Within 6 months of receiving test results, 76% of mutation carriers reported that they had undergone colonoscopy since receiving their results, a significantly greater proportion compared with baseline utilization and with noncarriers (F=18.87, p<0.001).  Compared with baseline responses, mutation uterine carriers also expressed significantly greater self-confidence in their ability to follow through with colonoscopy, a greater level of commitment to having colonoscopy, and fewer perceived barriers to CRC screening after test results disclosure. Undergoing HNPCC genetic counseling and testing may motivate mutation carriers to have a colonoscopy within a relatively short time period after disclosure of test results.
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