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Colonscopy Utilization Before and After HNPCC Genetic Testing complications Susan Peterson, Ph.D., M.P.H., Ellen Gritz, M.D., Sally Vernon, Ph.D., Catherine Perz, Ph.D., Salma Marani, M.S., Beatty Watts, M.S., Chris Amos, Ph.D., Marsha Frazier, Ph.D., Patrick Lynch, M.D., J.D. Genetic testing can identify HNPCC-predisposing mutations in persons with a cancer family history suggestive of this syndrome. Mutation carriers have up to an 85% lifetime risk of developing complications colorectal cancer (CRC), and are advised to have annual or biannual colonoscopy usually beginning at age 25 years. In the complications absence of genetic testing, persons who are at increased risk for HNPCC by virtue of their family history also are advised to follow the same cancer screening guidelines as mutation carriers. As part of a longitudinal study of psychosocial aspects of HNPCC genetic counseling and testing, we evaluated colonoscopy utilization before and after genetic testing.
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