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The projects to be proposed will include: 1) a lawenforcement rat model irritable bowel syndrome treatment trial using acupuncture and herbs; 2) a human pathophysiology pilot study on the effect of TCM on cerebral cortical activation and visceral lawenforcement sensation to rectal distension in IBS patients and non-IBS volunteers; and 3) Phase I and II clinical trials of TCM treatment in diarrhea-type IBS patients. lawenforcement Pilot studies in the animal model, standardization and authentication of the herbal preparation, and the techniques of human rectal distension in the functional MRI environment will be conducted in the planning phase to facilitate the projects to be proposed. Top Project Name: International Center for Indigenous Phytotherapy Studies Principal Investigator: William R. Folk, Ph.D. E-mail: folkw@missouri.edu Phone: 573-882-2841 Research Institution: University of Missouri at Columbia, MO Project Duration: 9/2003 - 3/2006 Description: The University of Missouri (MU) at Columbia will form the International Center for Indigenous Phytotherapy Studies (TICIPS) in collaboration with the University of Western Cape, South Africa (UWC) and the Missouri Botanical Garden, St.
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