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nondeprived) with nicotine spray (active vs. placebo) during which they viewed affective pictures (positive, negative, neutral) while startle probes were administered. A deprivation milf videos by picture valence interaction and a main effect for milf videos nicotine milf videos spray were found. Nicotine administration suppressed startle responding regardless of picture type and the interaction indicated that startle responses to negative stimuli were enhanced during nicotine deprivation and attenuated under conditions of normal smoking. These findings suggest nicotine deprivation predisposes the smoker to respond to negative emotional cues with enhanced activation of the defensive system while nicotine helps suppress defensive responding. Taken together, this evidence suggests nicotine influences brain structures related to drug motivation and emotion. Late Relapse in a Community SampleLudmila Cofta-Gunn, Ph.D.,
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